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Repetitive downward leak-age of secretions pooled above an ETT cuff, bio-?lm formation on the ETT surface, mucosaldamage, and impedance of mucociliary clearanceall contribute to colonization of lower airwaysecretions (Pneumatikos et al

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AUC ratiosare reported in the text where available. This rep-resents the simplest association to find and describe. Depending on the modal-ity of ventilation, compliance and resistance willaffect both phases of each variable

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